Uruguay's experienced squad will be without a key figure for the trip to Austria on Wednesday after Edinson Cavani pulled out injured.
The Paris Saint-Germain striker is one of the South American nation's headline attractions, along with Liverpool forward Luis Suarez, but was forced to withdraw from the initial 23-man selection last week to continue his recovery from a thigh injury.
National team coach Oscar Tabarez will have been thrilled, however, by the 27-year-old's goalscoring return to domestic action off the bench in PSG's 2-0 win over Marseille on Sunday.
While a blow to preparations for the 2014 FIFA World Cup, Cavani's absence does not leave Uruguay desperately short of experience, with the remaining members of the squad holding an average of 51 caps.
Indeed, only four members of the squad have made less than 20 international appearances.
At 34, Diego Forlan is the oldest head in the Uruguay camp and will make his 108th outing for his country if utilised at the Worthersee Stadion.
Tabarez's men reached the World Cup with a 5-0 play-off victory over Jordan, but opponents Austria will not be heading to Brazil in June after finishing third in their European qualification group behind Germany and Sweden.
The hosts have a good record on home soil, losing just three of their last 13 international matches in front of their own fans, but Austria have not come up against South American opposition since suffering a 2-0 home defeat to Chile in 2007.
Despite 36 places separating the two sides in the world rankings, Austria defender Sebastian Prodl believes his team can prove to be a stern test for their more illustrious visitors.
"We take this test very seriously," said the Werder Bremen man.
"There is to be no easy task against number seven in the FIFA world rankings, but we do not need to hide.
"We want to present ourselves well in Klagenfurt, but our goal is to qualify for the European Championship finals in France."
In addition to Cavani, Uruguay will be without Martin Caceres, who suffered a head injury in a collision with Andrea Poli in Juventus' 2-0 win at Milan on Sunday, and Abel Hernandez (chest).
|Coach: M. Koller|
for G. Garics 17'
for M. Harnik 46'
for R. Almer 46'
for Z. Junuzović 68'
for C. Leitgeb 71'
for M. Arnautović 81'
|Scotland call up debutants Gauld and May|
|Ramsey out for up to four weeks|
|Giroud deal done - Wenger|
|Hull City challenge FA over name change ruling|
|Rooney impressed with McNair|
|Luiz: I nearly joined Barca|
|Persipura 0 Al Qadsia 6 (agg 2-10): Visitors coast into final|
|Blanc wary of ´exceptional´ Messi|
|Dawson extends Albion deal|
|Mourinho open to move within Premier League|
|Top four the priority - Van Persie|
|Liga MX Preview: Queretaro braced for Atlas challenge|
|Copa Sudamericana Preview: Sao Paulo out to arrest slump|
|MLS Preview: DC United ready to grind, Revolution host Crew|
|Argentine Primera Division Review: Newell´s unbeaten run ends|
|Mignolet shrugs Valdes, Liverpool link|
|Neville blames transfers for Newcastle form|
|Mathieu applauds Messi, Neymar partnership|
|Mignolet must improve - Carragher|
|Cole hails Lampard|
|Villa may miss opener in Australia|
|Hughes thrilled with ´deserved´ home win|
|Pardew fears for future|
|Serie A Review: Djordjevic treble fires Lazio to Palermo win|
|Pardew facing ´serious conversations´ with Ashley|
|Pacos de Ferreira 2 Belenenses 0: Hosts off the mark on home turf|
|Stoke City 1 Newcastle United 0: Crouch deepens gloom for visitors|
|Garcia embracing underdogs tag|
|Turkish Super Lig Review: Gekas double sinks Fenerbahce|
|Bayer Leverkusen v Benfica: Schmidt´s men seek goalscoring touch|
|Costa to start against Sporting|
|Russian Premier League Review: CSKA edge Ural thriller to close gap on Zenit|
|Ludogorets v Real Madrid: Holders out to avoid slip-up in Sofia|
|Malmo v Olympiacos: Roberto insists no hangover for visitors|
|Championship Preview: McKinlay in at Watford, Norwich host unbeaten Charlton|
|Luis Enrique expecting stern PSG test|
|Atletico Madrid v Juventus: Opening defeat puts pressure on hosts|
|Bruce staying positive despite winless run|
|Police investigating Van Dijk racism claims|
|Hazard dreaming of Champions League glory|
|Santos goes to Goa|
|Double delight for Al-Garni|
|Basel v Liverpool: Rodgers hopeful on Sturridge return|
|Arsenal v Galatasaray: Wenger facing selection headache|
|Blanc calling on others to cover for Ibrahimovic absence|
|Zenit v Monaco: Jardim sticking with style|
|Ibrahimovic out of Barca clash|
|Lucescu happy to host Porto in Lviv|
|Hart looking to bounce back against Roma|
|McKinlay replaces Garcia at Watford|
|Anderlecht v Borussia Dortmund: Hasi expecting tough test|
|Sunderland not panicking, says Jones|
|Pelle hopes for Italy call|
|Slutsky well aware of Bayern strength|
|Guardiola entering unchartered territory|
|Arsenal have a point to prove against Chelsea - Oxlade-Chamberlain|
|Irvine hails Lescott impact|
|Carlos backs Ancelotti to defend crown|
|Montoya replaces injured Douglas|
|Pearce wants permanent Hunt deal|
|Nolan targets top 10|
|Mangala reaction pleases Kompany|
|Dyche keen to emulate West Brom example|
|Irvine happy to see Hawthorns rocking again|
|San Siro ´isn´t enough anymore´ for Milan|
|Redknapp calls for temporary subs|
|Western Sydney Wanderers v Seoul: A-League side look to continue dream run|
|Hazard rules out PSG switch|
|MLS Review: Keane scores twice in Galaxy romp|
|Costa Rican Primera Division Review: Five-star Alajuelense extend streak|
|Colombian Primera A Review: Medellin held, Santa Fe go top|
|Liga del Futbol Profesional Boliviano Review: Wilstermann remain top|
|Napoli rewarded for team effort - Benitez|
|Liga MX Review: Layun scores four, Monterrey leapfrog Atlas|
|Paraguayan Division Profesional Review: 15-year-old Diaz is Cerro´s hero|
|Uruguayan Primera Division Review: Racing leave it late, Recoba scores from a corner|
|Brazilian Serie A Review: Gremio´s resurgence continues|
|Venezuelan Primera Division Review: Leaders held, Tucanes win again|
|Referee got it right - Rooney|
|Peruvian Primera Division Review: Melgar stay perfect|
|Bielsa: Marseille always in control|
|Newcastle will offer Tiote new deal - Pardew|
|Shakhtar Donetsk v Porto: Lucescu looks to maintain impressive home record|
|Ligue 1 Review: Marseille, Bordeaux continue fine starts|
|Serie A review: Inter stunned, Sampdoria derby delight|
|APOEL v Ajax: De Boer hoping to end poor away form|
|Schalke v Maribor: Draxler set for return for confident hosts|
|Al Ahly 2 Coton Sport 1 (agg 3-1): Hosts secure historic final berth|
|Sporting Lisbon v Chelsea: Hosts protecting fearsome home record|
|CSKA Moscow v Bayern Munich: Robben calls for psychological focus|
|Primeira Liga Review: Gil Vicente´s misery continues|
|Bundesliga Review: Late Piazon strike stuns Hamburg, Augsburg edge out Hertha|
|Dyche wants Burnley to bounce straight back|
|Hard work paying off for West Brom - Irvine|
|Paris Saint-Germain v Barcelona: Blanc hopeful of Ibrahimovic return|
|Eredivisie Review: PSV lose at Heerenveen, Twente win|
|TP Mazembe 3 ES Setif 2 (agg 4-4): Away goals secure final berth for Algerians|
|West Brom 4 Burnley 0: Berahino shines in routine win|
|Mazzarri accepts blame for Cagliari humbling|
|Inzaghi frustrated with Milan draw|
|Manchester City v Roma: Zabaleta ready for crucial clash|
|CSL Review: Evergrande take dramatic Guangzhou derby|
|Cesena 1 Milan 1: Rami rescues point for Inzaghi´s men|
|Inter 1 Cagliari 4: Ekdal hat-trick inspires sensational away win|
|Reading 3 Wolves 3: Late Murray leveller earns draw|
|BATE v Athletic Bilbao: La Liga side look to kick-start season|
|Luiz needs time - Blanc|
|Every day is difficult - Guardiola|
|Martinez hails Hibbert and Browning|
|Lallana getting fitter - Rodgers|
|My best is yet to come - Rooney|
|K.League Review: Pohang snatch draw against leaders, Busan I´Park claim much-needed win|
|Chadli revels in derby goal|
|Al Ain v Al Hilal: Uphill battle for Dalic´s men|
|Koeman praises Mane and Bertrand|
|Costa needs 15 days to recover - Mourinho|
|Serie A not a two-horse race - Tevez|
|MLS Review: Seattle go top, Toronto fight back to win|
|Atletico were simply better - Emery|
|Gerrard: I´m not finished yet|
|Persipura v Al Qadsia: Visitors set to reach final|
|Kitchee v Erbil: Belencoso key for hosts|
|Ecuadorian Primera A Review: Barcelona continue good form|
|Sakho sorry for pre-game departure|
|Berahino ´lost´ after Clarke exit|
|La Liga Review: Big guns win|
|Home fans key to Atletico success - Simeone|
|Primeira Liga Review: Benfica win thriller, Braga beat Rio Ave|