Argentine clubs River Plate and Lanus booked their Copa Sudamericana spots in the next round, with contrasting aggregate victories.
River Plate trailed Ecuadorian outfit LDU Loja 2-1 after their first leg in Ecuador, with their away goal meaning a 1-0 win would have got the Argentines over the line.
And when Teofilo Gutierrez struck on 36 minutes, the game was on the terms of Ramon Diaz River Plate side.
Manuel Lanzini wrapped up the aggregate victory with a well-struck goal in the 71st minute, to win the leg 2-0 for the hosts in Buenos Aires.
Lanus were already virtually assured of a last-eight spot after a 4-0 first leg win over Universidad de Chile, and on their second-leg trip to Santiago, they limited the damage to a 1-0 loss.
Charles Aranguiz scored the winning goal in the leg for Universidad de Chile on 69 minutes.
In this week's first leg encounters, Coritiba blew their home leg against Itagui, slumping to a 1-0 loss.
The Brazilian hosts were trumped by a goal in the first minute after the half-time interval, as Yessi Mena fired the Colombian visitors a valuable away goal.
Fellow Brazil Serie A side Sport Recife were beaten 2-0 away to Libertad, with first-half goals to Gustavo Gomez and Pedro Benitez handing the Paraguayans a handy lead at the tie's midway point.
There was better news for Brazilian club Ponte Preta, who opened up a two-goal advantage late in their 2-0 win over Colombian outfit Deportivo Pasto.
Fellipe Bastos struck deep into second-half injury time, to follow up Uendel's opener on 31 minutes for the hosts in Sao Paulo.
City rivals Sao Paulo were held to a 1-1 home stalemate by Chilean club Universidad Catolica, while an own goal from Bahia midfielder Diones handed a 1-0 win to Colombia's Atletico Nacional in Medellin.
|10||M. Lanzini||64' 71'|
|Coach: R. Díaz|
for C. Ledesma 46'
for A. Rojas 46'
for F. Andrada 80'
|Ozil blow for Arsenal|
|Simeone salutes second-half display|
|Championship Wrap: Reading stun Leeds, Blackpool end barren streak|
|UEFA Champions League: Bayern Munich 1 Arsenal 1 (3-1 agg)|
|UEFA Champions League: Atletico Madrid 4 Milan 1 (5-1 agg)|
|AFC Champions League Wrap: Mariners overcome Sanfrecce, Seoul held|
|Cousillas: City can stun Barca|
|UEFA Europa League Preview: Sevilla v Real Betis|
|Charlton appoint Riga|
|New deal for Heimeroth|
|FA reject Walters appeal|
|Mertens tipped for starring role|
|Aluko getting back to his best|
|UEFA Europa League Preview: Lyon v Viktoria Plzen|
|Grosso takes control of Juve´s youth team|
|Blanc: PSG still playing Euro catch-up|
|Kaboul ban overturned|
|Pardew hit with seven-game ban|
|McCann blow for Wigan|
|Cabaye has no regrets over PSG move|
|Martinez taking no risks with Jagielka|
|I turned down Juve in 2012 - Robben|
|Lambert wants more from Tonev|
|Wanchope: City can beat Barcelona|
|Wanchope: City can beat Barcelona|
|UEFA Europa League Preview: Tottenham v Benfica|
|Remy hungry for World Cup place|
|Martino: We have not been consistent|
|UEFA Europa League Preview: Ludogorets v Valencia|
|Inter unlikely to make moves for Dzeko, Torres|
|American firm acquire United shares|
|Callejon predicting strong Napoli era|
|UEFA Europa League Preview: Juventus v Fiorentina|
|Eto´o hints at Chelsea stay|
|Hughton pleased with Bassong performances|
|Barca treble still on the cards - Alexis|
|Monk: Michu close to Swansea return|
|Solskjaer hoping to inspire Cardiff strikers|
|Toprak: Restoring pride is important|
|UEFA Europa League Preview: AZ v Anzhi|
|Charlton sack Powell after FA Cup exit|
|UEFA Europa League Preview: Basel v Red Bull Salzburg|
|Move on from Diouf blow - Dufner|
|Fonte backs Rodriguez for World Cup|
|Stoke fear extended Huth absence|
|Anichebe calls for West Brom spirit|
|Courtois rubbishes Real rumours|
|Zenit thank sacked Spalletti|
|Manchester City positive ahead of Barcelona trip|
|Martinez hopes for Deulofeu stay|
|Kroos undecided on future|
|CONCACAF Champions League: Alajuelense 0 Arabe Unido 0|
|Argentina Primera Division Wrap: Velez Sarsfield close in on top|
|Paraguay Division Profesional Wrap: Nacional Asuncion into second|
|De Boer planning Ajax stay|
|UEFA Europa League Preview: Porto v Napoli|
|La Liga Wrap: Strugglers Rayo, Malaga pick up valuable away wins|
|Primeira Liga: Maritimo 2 Vitoria Guimaraes 1|
|UEFA Champions League Preview: Paris Saint-Germain v Bayer Leverkusen|
|Turkish Super Lig Wrap: Fenerbahce, Trabzonspor clash abandoned|
|Seedorf upbeat over Milan chances|
|Wenger outlines Arsenal belief|
|Russian Premier League Wrap: Lokomotiv go top, Anzhi post first win|
|UEFA Champions League Preview: Barcelona v Manchester City|
|Castro calls for fans´ support|
|Survival fight wide open, says Mutch|
|Bruce calls for league focus|
|Hoeness admits tax fraud|
|Shea returns to Stoke|
|Van den Brom leaves Anderlecht|
|Stevens ready for Stuttgart challenge|
|Liverpool clash excites Carrick|
|Villa eyeing top-half finish, claims Bertrand|
|Silva happy to remain in Paris|
|Gosling admits FA charge|
|Getafe confirm Contra as new coach|
|Reina considers future America move|
|Giroud: We must believe against Bayern|
|Wolves lodge complaints over alleged racist abuse|
|Gladbach sign Sommer to replace Ter Stegen|
|Getafe part company with Garcia|
|Strootman World Cup hopes in serious doubt|
|Clyne backs Palace to survive|
|Liverpool striving for perfection, says Allen|
|Simeone expecting tough Milan test|
|De Guzman confident ahead of West Brom clash|
|Guardiola wary of Arsenal threat|
|Mel speculation is ´crazy´, says Foster|
|Taarabt not fearing Atletico|
|Mourinho expects to lose Torres for ´couple of weeks´|
|Heitinga: Survival a trophy for Fulham|
|Carvajal plays down injury fears|
|Oxlade-Chamberlain eyes Arsenal cup success|
|Benitez praises Reina, Higuain|
|Shaw focusing on Southampton not England|
|Bayern must be aggressive, says Guardiola|
|Venezuela Primera Division Wrap: Zamora increase advantage with Tachira scalp|
|Uruguay Primera Division Wrap: Nacional capitalise on Fenix fumble|
|Liga MX Wrap: Tigres UANL end Cruz Azul unbeaten run|
|Ecuador Primera A Wrap: Independiente, Loja slip up to send Emelec top|
|Costa Rica Primera Division Wrap: Wins for Herediano, Deportivo Saprissa|
|Liga del Futbol Profesional Boliviano Wrap: Club Universitario open gap|
|Chile Primera Division Wrap: Colo Colo cruise past Union La Calera|
|Benitez: 11th-hour injuries could not halt Napoli|
|La Liga Wrap: Real capitalise on Barca slip-up, Valencia and Bilbao draw|
|Primeira Liga Wrap: Benfica extend lead, Porto close in on Sporting|
|Garcia frustrated by toothless Roma|