Rickie Lambert is out of England’s friendly against Chile on Friday night and fellow striker Daniel Sturridge is rated as doubtful.
Southampton striker Lambert has a muscle injury that could also keep him out of Tuesday night’s clash with Germany at Wembley, England coach Roy Hodgson has confirmed.
Liverpool frontman Sturridge is expected to miss out against Chile due to a foot problem, but he could feature against Joachim Low’s side next week.
Frank Lampard will captain the side in the absence of Steven Gerrard, who is also injured along with Kyle Walker, Michael Carrick and Danny Welbeck.
"We've lost Rickie Lambert to a muscle problem, it will keep him out of the game on Friday and possibly out of the Germany game," said Hodgson.
"Gerrard and Walker will miss game against Chile but will hopefully be ready for Germany. I've got to speak to the doctors about Daniel Sturridge and get a full update. Chances are he'll be spared for the first game."
Hodgson also revealed that out-of-favour Manchester City goalkeeper Joe Hart will not start against Chile, so either Celtic keeper Fraser Forster or Norwich City's John Ruddy will get their opportunity to stake a claim for the number one spot ahead of next year's FIFA World Cup.
"Joe Hart won't be starting, you will have to work out for yourself which of the others won't," he said.
"John was with us from the beginning and I have had time with him and have had Fraser with us for over a year. I will make that decision on whether I choose both or one tomorrow."
Southampton duo Jay Rodriguez and Adam Lallana will make their debuts against the South Americans, but Hodgson refused to say whether they feature from the start.
"I don't want to get drawn into it (naming his team). I haven't spoken to the players about the team," he added.
"Frank knows and I have spoken to the Southampton boys and told them they will feature. That's all I'm going to say."
Lampard will make his 103rd appearance for his country and the Chelsea midfielder will be presented with a gold cap by his father and Sir Geoff Hurst before kick-off on Friday.
"It will be a very special moment for me," he said.
"To win 100 caps was a long time coming and I've seen gold caps given to Stevie (Gerrard) and Ashley (Cole) and the idea of Sir Geoff being involved came from the FA, but it's one I'm very happy with.
"I requested my dad was involved as well and he will be very proud."
|Coach: R. Hodgson|
for J. Rodriguez 57'
for P. Jones 57'
for J. Milner 66'
for F. Lampard 71'
for J. Wilshere 71'
for A. Lallana 77'
|West Brom overcome Sacramento|
|Colorado Rapids 3 Chivas USA 0: Hosts rise to third in the West|
|Gameiro brace adds to West Ham woes|
|Villas-Boas: Rodriguez best suited to no.10 role|
|Cazorla: I´m happy at Arsenal|
|Reina respects Liverpool contract|
|Lampard could move to Melbourne on loan|
|Galliani: Balotelli ´99.9 per cent´ staying|
|Own goal helps Palace win in Philadelphia|
|Mourinho: Shaw deal would have ´killed´ Chelsea|
|Al Ahli Benghazi 0 ES Setif 2: Visitors on verge of semi-final spot|
|Julio Cesar returns to QPR|
|Rooney wants to lead United|
|Lallana to miss up to six weeks with knee injury|
|Isgrove maintains Koeman´s perfect start|
|Lens announce Ligue 1 appeal success|
|Pekerman talks due in August|
|PSG sanction ´harsh´, claims FFF chief|
|Garcia: Strootman going nowhere|
|Van Aanholt departs Chelsea for Sunderland|
|Benfica sign Manchester United flop Bebe|
|Campbell makes Palace move|
|Reed signs new deal at Southampton|
|Juve stunned in Allegri´s first match|
|AFA fined over Falklands banner|
|Robinho likely to move, claims agent|
|Drogba completes Chelsea return|
|Kiyotake moves to Hannover|
|Marotta: Juventus eyeing striking additions|
|Bakayoko set for Monaco switch|
|J.League Preview: Vortis out to improve dismal fortunes against Ardija|
|Juve complete Pereyra deal|
|Ranieri named Greece head coach|
|Fiorentina agree Basanta deal|
|Di Natale backs Pereyra´s Juve move|
|Iniesta: Suarez has talent to restore Barca glory|
|Cerci in charge of his future, says Cairo|
|West Ham target new striker|
|Pardew hopeful over De Jong|
|Rodgers expects new Gerrard deal|
|Jones: United embracing Van Gaal methods|
|Henry: Time had come to sell Suarez|
|Brunt eyes new West Brom deal|
|Arsenal´s World Cup winners to miss league opener|
|Modric hails Rodriguez, Kroos signings|
|Cech does not want bench role|
|Inzaghi blames fatigue for Milan loss|
|Real´s time to shine, says Ancelotti|
|Real Salt Lake 3 Montreal Impact 1: Garcia stars in Utah|
|Downing: Carroll injury a ´big blow´|
|Irvine: I have not seen Ideye play live|
|Olympiacos triumph in Toronto|
|Giggs likens Van Gaal to Ferguson|
|Copa do Brasil Review: Corinthians among trio on the verge of progression|
|Blanc: World Cup stars will move on|
|Pinto steps down as Costa Rica coach|
|Mourinho planning Drogba swoop|
|UEFA Europa League Review: Rosenborg complete comeback to see off Sligo|
|Mathieu out to enjoy Barcelona move|
|Mandzukic not Diego Costa´s replacement|
|Eliseu returns to Portugal with Benfica|
|Sanabria makes Roma switch|
|Carroll to miss start of season|
|Vidal: I´m not going to Manchester|
|Xavi staying at Barcelona|
|Hannover complete Gulselam signing|
|Astori loaned to Roma, Cagliari confirm|
|Nigeria to talk with Keshi over return|
|Gamberini makes Chievo move|
|Besic poised to complete Everton move|
|Marseille move Montpellier fixture from Stade Velodrome|
|CSL Preview: Harbin eye Luneng scalp, Guangzhou face Hena|
|Guardiola preaches patience with Lewandowski|
|Lampard joins New York City|
|Blanc coy on Di Maria speculation|
|CAF Confederation Cup Preview: ASEC coach confident, Al Ahly seek qualification|
|Chelsea loan Piazon to Frankfurt|
|Pochettino has high hopes for Lamela|
|Aguirre appointed as Japan coach|
|Swansea swoop for Montero|
|Pozuelo makes Vallecano switch|
|Fred back at Shakhtar, Ismaily to follow|
|CFF investigate Fofana accusations|
|Suarez could make sensational Clasico debut|
|Ribery in line for return, says Guardiola|
|Reus could resume training in two or three weeks - Klopp|
|Roma need another defender, says Garcia|
|Everton on verge of new signings|
|Rodrigo hails Nuno after Valencia switch|
|Delph eager for new Villa deal|
|Ljajic not seeking Roma exit|
|Talks held as players strike in Ecuador|
|Crouch excited by Bojan capture|
|Lambert expects swift recovery for Cole|
|West Ham duo fail to travel|
|United to play 3-4-3, says Van Gaal|
|Lallana, Markovic set to feature against Olympiacos|
|Real want to win every trophy, says Bale|
|San Jose Earthquakes 5 Chicago Fire 1: Hosts break winless streak|
|Chelsea have "outstanding squad" - Costa|
|United make winning start under Van Gaal|
|Rodgers plays down Borini injury concerns|
|Atletico Mineiro 4 Lanus 3 (agg 5-3): Own goals gift Brazilians the win|
|Dunga names Brazil assistants|
|Man City show class in Kansas|
|Villa too good for Dallas|
|Santos cannot meet Robinho´s demands, says vice-president|
|Mourinho happy with goalkeeper situation|
|Borini hurt as Liverpool lose to Roma|
|Palace held to draw by Crew|
|Tottenham down Toronto after Lamela brace|
|San Lorenzo 5 Bolivar 0: Hosts close in on Copa Libertadores final|
|Sunderland forward Scocco joins Newell´s|
|Rodgers: We won´t overpay in transfer market|
|Maccabi Haifa friendly abandoned after pitch invasion|
|USA dynamo Beasley joins Houston|